解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::It has been highlighted that the original manuscript [1] contains a typesetting error in the surname of Jesson Butcon. This was incorrectly captured as Jessica Butcon in the original manuscript which has since been updated. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-018-4105-3
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The centralisation of specialist cancer surgical services across London Cancer and Greater Manchester Cancer, England, may significantly change how patients experience care. These centres are changing specialist surgical pathways for several cancers including prostate, bladder, kidney, and oesophago-gastric ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4137-8
更新日期:2018-02-27 00:00:00
abstract:BACKGROUND:There is currently limited information regarding the prognostic ability of the dNLR-PNI (the combination of the derived neutrophil-to-lymphocyte ratio [dNLR] and prognostic nutritional index [PNI]) for hepatocellular carcinoma (HCC). This study aimed to assess the predictive ability of the dNLR-PNI in patien...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4121-3
更新日期:2018-02-21 00:00:00
abstract:BACKGROUND:Aberrant methylation is a frequent event in oral cancer. METHODS:In order to better characterize these alterations, a search for genes downregulated by aberrant methylation in oral squamous cell carcinoma (OSCC) was conducted through the mining of ORESTES dataset. Findings were further validated in OSCC cel...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4077-3
更新日期:2018-02-17 00:00:00
abstract:BACKGROUND:Lung cancer patients with an activating mutation in the EGFR (epidermal growth factor receptor) can develop resistance to erlotinib treatment, which is often mediated by the T790M resistance mutation in EGFR. The difficulties in obtaining biopsies at progression make it challenging to investigate the appeara...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4108-0
更新日期:2018-02-15 00:00:00
abstract:BACKGROUND:There is now a renewed interest in cancer vaccines. Patients responding to immune checkpoint blockade usually bear tumors that are heavily infiltrated by T cells and express a high load of neoantigens, indicating that the immune system is involved in the therapeutic effect of these agents; this finding stron...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4094-2
更新日期:2018-02-13 00:00:00
abstract:BACKGROUND:HtrA1 is expressed in a variety of normal human tissues and seems to be involved in numerous physiological processes as well as tumorigenesis. This study reports the results of a meta-analysis that was performed: to compare HtrA1 expression as mRNA and protein, in cancer tissue versus non-cancer tissue and t...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-018-4041-2
更新日期:2018-02-06 00:00:00
abstract:BACKGROUND:Pancreas ductal adenocarcinoma (PDAC) has the most dismal prognosis among all human cancers since it is highly resistant to chemotherapy, radiotherapy and immunotherapy. The anticipated consequence of all therapies is induction of tumor apoptosis. The highly resistance nature of PDACs to all therapies sugges...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4061-y
更新日期:2018-02-06 00:00:00
abstract:BACKGROUND:Immunotherapies have advanced the treatment of metastatic melanoma; however, they are associated with immune-related toxicities. Patients with pre-existing autoimmune comorbidities are commonly excluded from clinical trials investigating immunotherapies in metastatic melanoma. Since information on pre-existi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4051-0
更新日期:2018-02-06 00:00:00
abstract:BACKGROUND:Although adjuvant chemotherapy with S-1 after curative gastrectomy has been performed as a standard treatment for Stage II and III gastric cancer (GC) in Japan, patients with Stage III GC still have a high incidence of recurrence and a poor prognostic outcome. The aim of this study was to investigate risk fa...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4052-z
更新日期:2018-01-30 00:00:00
abstract:BACKGROUND:Deaf people represent 0.1% of the French population and their access to public health campaigns is limited due to their frequent illiteracy and the infrequent use of sign language in campaigns. There is also a lack of general health knowledge in spite of the existence of French Deaf Care Units (UASS). The ai...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3972-3
更新日期:2018-01-23 00:00:00
abstract:BACKGROUND:FAM3B/PANDER is a novel cytokine-like protein that induces apoptosis in insulin-secreting beta-cells. Since in silico data revealed that FAM3B can be expressed in prostate tumors, we evaluated the putative role of this cytokine in prostate tumor progression. METHODS:FAM3B expression was analyzed by quantita...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3950-9
更新日期:2018-01-22 00:00:00
abstract::After publication of the original article [1] the authors found that the article contained an incorrect version of Fig. 4. This does not affect the results and conclusions of the article. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-017-3766-7
更新日期:2018-01-16 00:00:00
abstract:BACKGROUND:The objective of this study is to investigate the role and experience of early stage non-small cell lung cancer (NSCLC) patient in decision making process concerning treatment selection in the current clinical practice. METHODS:Stage I-II NSCLC patients (surgery 55 patients, SBRT 29 patients, median age 68)...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-3986-5
更新日期:2018-01-15 00:00:00
abstract:CORRECTION:After publication of the original article [1] the authors found that the figure contained an incorrect version of Fig. 3a. This does not affect the results and conclusions of the article. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-017-3767-6
更新日期:2018-01-11 00:00:00
abstract:BACKGROUND:The prognostic variability of thyroid carcinomas has led to the search for accurate biomarkers at the molecular level. Follicular thyroid carcinoma (FTC) is a typical example of differentiated thyroid carcinomas (DTC) in which challenges are faced in the differential diagnosis. METHODS:We used high-throughp...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3948-3
更新日期:2018-01-10 00:00:00
abstract:BACKGROUND:Cancer cell resistance to therapeutics can result from acquired or de novo-mediated factors. Here, we have utilised advanced breast cancer cell culture models to elucidate de novo doxorubicin resistance mechanisms. METHODS:The response of breast cancer cell lines (MCF-7 and MDA-MB-231) to doxorubicin was ex...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3953-6
更新日期:2018-01-06 00:00:00
abstract:BACKGROUND:Activated pancreatic stellate cells (PaSCs) are the key cellular source of cancer-associated fibroblasts in the pancreatic stroma of patients with pancreatic ductal adenocarcinoma (PDAC), however, the activation mechanism of PaSCs is not yet known. The Notch signaling pathway, components of which are express...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3957-2
更新日期:2018-01-05 00:00:00
abstract:BACKGROUND:The goal of this exploratory study was to develop and assess a prediction model which can potentially be used as a biomarker of breast cancer, based on anthropometric data and parameters which can be gathered in routine blood analysis. METHODS:For each of the 166 participants several clinical features were ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3877-1
更新日期:2018-01-04 00:00:00
abstract:BACKGROUND:Glioblastoma relapses in the vast majority of cases within 1 year. Maximum safe resection of the recurrent glioblastoma can be offered in some cases. Re-irradiation has been established for the treatment of recurrent glioblastoma, too. In both cases, adjuvant treatment, mostly using temozolomide, can improve...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-017-3928-7
更新日期:2018-01-03 00:00:00
abstract:BACKGROUND:Glioma stem cells (GSCs) contribute to tumor recurrence and drug resistance. This study characterizes the tumorigenesis of CD133+ cells and their sensitivity to pharmacological inhibition. METHODS:GSCs from human U87 and rat C6 glioblastoma cell lines were isolated via magnetic cell sorting using CD133 as a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3924-y
更新日期:2017-12-29 00:00:00
abstract:BACKGROUND:No consensus treatment has been reached for hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). Hepatic resection (HR) and transarterial chemoembolization (TACE) have been recommended as effective options, but which is better remains unclear. This meta-analysis is to compare the effectiven...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12885-017-3895-z
更新日期:2017-12-28 00:00:00
abstract:BACKGROUND:Sorafenib is a multiple receptor tyrosine kinase inhibitor known to prolong overall survival in patients with advanced hepatocellular carcinoma (HCC). Predicting this drug's survival benefits is challenging because clinical responses are rarely measurable during treatment. In this study, we hypothesized that...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3889-x
更新日期:2017-12-19 00:00:00
abstract:BACKGROUND:Obesity is linked to poor disease outcomes in breast cancer patients. However, this link was mostly based on body weight or BMI rather than body-fat. The purpose of this study was to evaluate the relationship between body-fat gain and disease progression in Taiwanese women after breast cancer surgery and how...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3869-1
更新日期:2017-12-18 00:00:00
abstract:BACKGROUND:Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to have poor-risk cytogenetics, leading to poor response and prognosis. More than one-half of all older (≥...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-017-3803-6
更新日期:2017-12-14 00:00:00
abstract:BACKGROUND:In Chile, more than 500 women die every year from cervical cancer, and a majority of Chilean women are not up-to-date with their Papanicolau (Pap) test. Mobile health has great potential in many health areas, particularly in health promotion and prevention. There are no randomized controlled trials in Latin ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3870-8
更新日期:2017-12-13 00:00:00
abstract:BACKGROUND:High levels of blood glucose are thought to be associated with colorectal cancer (CRC) and hyperinsulinemia, an interstage in the development of CRC. The purpose of this study was to examine associations between incident CRC and blood glucose; plasma insulin; and the homeostasis model assessment for insulin ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3874-4
更新日期:2017-12-12 00:00:00
abstract:BACKGROUND:Computational intelligence methods, including non-linear classification algorithms, can be used in medical research and practice as a decision making tool. This study aimed to evaluate the usefulness of artificial intelligence models for 5-year overall survival prediction in patients with cervical cancer tre...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3806-3
更新日期:2017-12-12 00:00:00
abstract:BACKGROUND:Invasive micropapillary carcinoma (IMPC) of the breast is a rare variant of invasive ductal carcinoma (IDC). The prognosis of IMPC compared with that of IDC remains controversial; we conducted a meta-analysis to evaluate the prognostic difference between IMPC and IDC. METHODS:We searched the PubMed, Cochran...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-017-3855-7
更新日期:2017-12-11 00:00:00
abstract:BACKGROUND:Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this integrin has also been reported on several solid tumors, including colorectal cancer. However, its fu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3823-2
更新日期:2017-12-06 00:00:00
abstract:BACKGROUND:Overexpression of Cullin7 is associated with some types of malignancies. However, the part of Cullin7 in hepatocellular carcinoma remains unclear. The aim of this study was to investigate the role of Cullin7 in pathogenesis and the progression of hepatocellular carcinoma. METHODS:In the present study, the e...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3839-7
更新日期:2017-12-06 00:00:00
abstract:BACKGROUND:The need for novel biomarkers that could aid in non-small cell lung cancer (NSCLC) detection, together with the relevance of Matrix Metalloproteases (MMPs) -1, -2, -7, -9 and -10 in lung tumorigenesis, prompted us to assess the diagnostic usefulness of these MMPs and the Tissue Inhibitor of Metalloproteinase...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3842-z
更新日期:2017-12-05 00:00:00
abstract:BACKGROUND:For metastatic spinal cord compression (MSCC), conventional radiotherapy with 10 × 3 Gy in 2 weeks results in better local progression-free survival (LPFS) than 5 × 4 Gy in 1 week. Since patients with MSCC are often significantly impaired, an overall treatment time of 1 week would be preferable if resulting ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3844-x
更新日期:2017-12-04 00:00:00
abstract:BACKGROUND:Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells is unknown. METHODS:To investigate the effects and mechanisms of genistein on EMT of colon cancer ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3829-9
更新日期:2017-12-04 00:00:00
abstract:BACKGROUND:Whether perioperative blood transfusions (PBTs) adversely influence oncological outcomes for intrahepatic cholangiocarcinoma (ICC) patients after curative resection remains undetermined. METHODS:Of the 605 patients who underwent curative liver resection for ICC between 2000 and 2012, 93 received PBT. We con...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3745-z
更新日期:2017-11-14 00:00:00
abstract:BACKGROUND:The association of genes XRCC1, TP53 and MDM2 with breast cancer (BC) has never been tested in Kyrgyz population. We, therefore, aimed to identify an association of alleles and genotypes of polymorphic markers Arg399Gln of gene XRCC1, Arg72Pro of gene TP53, and T309G of gene MDM2 with the risk of BC in Kyrgy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3762-y
更新日期:2017-11-13 00:00:00
abstract:BACKGROUND:Growing evidence has indicated that some inflammatory markers, including lymphocyte to monocyte ratio (LMR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and prognostic nutritional index (PNI), can be used as indicators in the prognosis of colorectal cancer (CRC). However, there ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3752-0
更新日期:2017-11-10 00:00:00
abstract:BACKGROUND:Pneumatosis cystoides intestinalis (PCI) is a rare self-limiting condition characterized by air-filled cysts within intestinal walls. Diagnosis should be prudent because it can mimic pneumoperitoneum leading to unnecessary treatment such as surgical exploration. Although various drugs including anti-neoplast...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-017-3744-0
更新日期:2017-11-09 00:00:00
abstract:BACKGROUND:There are three main therapeutic strategies, namely expectant management (dilation and curettage only), prophylactic chemotherapy and prophylactic total hysterectomy for treating older women with complete hydatidiform mole (CHM). However, the scientific community has so far, not unanimously accepted the abov...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3749-8
更新日期:2017-11-09 00:00:00
abstract:BACKGROUND:Liver resection had been regarded as a standard treatment for primary hepatocellular carcinoma (HCC). However, early mortality and recurrence after surgery were still of major concern. RAM (Risk Assessment for early Mortality) scoring system is a newly developed tool for assessing early mortality after hepat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3748-9
更新日期:2017-11-09 00:00:00